For the third time in 2022, Cambodia was the ASEAN chair. In terms of current world events, it also denotes a crucial year for Cambodia, as it had to deal with numerous global and regional problems. In this regard, Cambodia’s main priority during its ASEAN chairmanship is economic diplomacy to boost local and regional prosperity in the face of the looming global economic crisis and uncertainties of the international political system. This article examines what Cambodia has done and will continue to do to enhance its economic diplomacy during its 2022 ASEAN chairmanship and beyond.